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gerE [2017-12-15 17:16:25]
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gerE [2017-12-15 17:16:25]

transcriptional regulator (repressor or activator) of a subset of [protein|search|SigK sigma-K]-dependent late spore coat genes
locus
BSU28410
pI
9.64
mw
8.43 kDa
protein length
74 aa Sequence Blast
gene length
222 bp Sequence Blast
function
regulation of [protein|search|SigK]-dependent gene expression
product
transcriptional regulator (LuxR-FixJ family)
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.4|Germination] → [category|SW 4.2.4.2|Additional germination proteins]

    • Gene

    Coordinates
    2,904,727 → 2,904,951

    Phenotypes of a mutant

  • unable to germinate efficiently [Pubmed|3139490]

    • The protein

    Protein family

  • LuxR-FixJ family of transcription regulators

    • Structure

  • [PDB|1FSE]

    • additional information

  • information on binding sites can be found in the [http://www.prodoric2.de/detail.php?acc=MX000047 PRODORIC2 database]

    • Expression and Regulation

    Operons

    genes
    [gene|19228BAD44E6DA3DE908DC390FDF628C18D94E65|gerE]
    description
    [Pubmed|3114423]

    sigma factors

  • [protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK]: sigma factor, [Pubmed|15699190], in [regulon|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK regulon]

    • regulatory mechanism

  • [protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID]: activation, [Pubmed|7896717], in [regulon|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID regulon]
  • [protein|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|CitB]: mRNA binding, results in mRNA accumulation [Pubmed|16923907], in [regulon|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|CitB regulon]

    • regulation

  • expressed late during sporulation in the mother cell ([protein|search|SigK], [SW|SpoIIID]) [Pubmed|15699190,7896717]
    • view in new tab

    Biological materials

    Mutant

  • BKE28410 (Δ[gene|19228BAD44E6DA3DE908DC390FDF628C18D94E65|gerE]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE28410 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGTATTGTAACCCTCCTT, downstream forward: _UP4_TAATCCTTGCCGGTATTCCT
  • BKK28410 (Δ[gene|19228BAD44E6DA3DE908DC390FDF628C18D94E65|gerE]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK28410 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGTATTGTAACCCTCCTT, downstream forward: _UP4_TAATCCTTGCCGGTATTCCT

    • Labs working on this gene/protein

  • [SW|Arthur Aronson], Purdue University, West Lafayette, USA [http://wwwdev.gradschool.purdue.edu/PULSe/faculty.cfm?fid=5&range=0 homepage]
  • [SW|Charles Moran], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage]

    • References

  • 7519271,2474075,11418558,10400595,7592393,11741866,7592342,3135411,9852018,1691789,15383836,11150673,1518043,7814326,14523132,12031481,11418558,3114423,7896717,11243786,17890309,15470121,20435725,21670523,23064347,3139490,25259857,6787012,26279233,16923907